Clinical Trials

In addition to the advances we have made in basic science and translational research, the Dean McGee Eye Institute remains at the forefront of clinical medicine through our Clinical Trials initiative. Here at the institute, our physicians are investigating the latest in drug development and treatment strategies for a number of eye conditions. These studies are funded by the National Eye Institute (NEI) and pharmaceutical industry.

Clinical trials are an essential step to foster the best in patient care while also offering patients the most modern, cutting edge treatment. Patients choose to participate in clinical trials for many reasons; they may have the opportunity to receive treatments with tremendous promise but are unavailable outside of a trial, or some simply appreciate the intrinsic feeling of contributing to the advancement of science.

See below for the current list of clinical trials at the Dean McGee Eye Institute in a wide variety of ophthalmology services.

Additional information for all studies can be found on www.clinicaltrials.gov.

Neuro-Ophthalmology

Study Name: A Multicenter, Partially-Masked, Randomized, Controlled Study of Medical Therapy vs. Medical Therapy plus Optic Nerve Sheath Fenestration vs. Medical Therapy plus Stereotactic Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects with Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss (“SIGHT”)
Condition(s) under Study: Idiopathic Intracranial Hypertension with Moderate to Severe Visual Loss
Sponsor: NEI and Icahn School of Medicine at Mount Sinai
Study Summary: Study will compare effectiveness of 1) medical therapy, 2) optic nerve sheath fenestration plus medical therapy and 3) ventriculo-peritoneal CSF shunting plus medical therapy in newly diagnoses patients with Intracranial Hypertension of unknown origin with visual loss.
Investigator(s): Dr. Anil Patel
ClinicalTrials.gov Information: NCT03501966


Pediatric

Study Name: Binocular Dig Rush Game Treatment for Amblyopia (ATS20)
Condition(s) under Study: Ambylopia
Sponsor: Jaeb Center for Health Research
Study Summary: To compare the effectiveness of 1 hour/day of binocular game play 5 days per week with continued optical correction to optical correction alone, in children 4 to <7 years of age.
Investigator(s): Dr. R.M. Siatkowski
ClinicalTrials.gov Information: Identifier: NCT02983552


Study Name: Cerebrotendinous Xanthomatosis Prevalence Study
Condition(s) under Study: Cerebrotendinous Xanthomatosis (CTX)
Sponsor: Retrophin, Inc.
Study Summary: Observational study to determine the prevalence of CTX in patients diagnosed with early-onset bilateral cataracts
Investigator(s): Dr. Maria Lim
ClinicalTrials.gov Information: NCT02638220

Retina

Study Name: Treatment of Central-Involved DME (Protocol AC)
Condition(s) under Study: Diabetic Macular Edema
Study Summary:
A randomized trial of intravitreous Aflibercept versus intravitreous Bevacizumab plus deferred Aflibercept for treatment of central involved diabetic macular edema.
Investigator(s): Dr. Ronald Kingsley
ClinicalTrials.gov Information: NCT03321513


Study Name: PANDA2
Condition(s) under Study: Age-related Macular Degeneration (Wet)
Sponsor:  Chengdu Kanghong Biotechnology
Study Summary:
A randomized trial of intravitreous Conbercept at two different doses versus intravitreous Aflibercept in subjects with Neovascular Age-related Macular Degeneration
Investigator(s): Dr. Ronald Kingsley
ClinicalTrials.gov Information: NCT03630952


Study Name: Genes in Diabetic Retinopathy Project
Condition(s) under Study: Diabetic eye conditions
Sponsor: Diabetic Retinopathy Clinical Research Network
Study Summary: A one time, blood sample collection study looking at genetic susceptibility and resistance to Diabetic Retinopathy and other variants impacting visually-important biomarkers for macular edema and neovascularization.
Investigator(s): Dr. Ronald Kingsley
ClinicalTrials.gov Information: None available.



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